FOBISIN 101

CAS No. 1370281-06-3

FOBISIN 101( FOBISIN101 )

Catalog No. M11527 CAS No. 1370281-06-3

FOBISIN 101 is a small molecule 14-3-3 protein-protein interaction inhibitor with IC50 of 9.3 and 16.4 uM for the binding of 14-3-3ζ or 14-3-3γ to PRAS40, respectively.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    FOBISIN 101
  • Note
    Research use only, not for human use.
  • Brief Description
    FOBISIN 101 is a small molecule 14-3-3 protein-protein interaction inhibitor with IC50 of 9.3 and 16.4 uM for the binding of 14-3-3ζ or 14-3-3γ to PRAS40, respectively.
  • Description
    FOBISIN 101 is a small molecule 14-3-3 protein-protein interaction inhibitor with IC50 of 9.3 and 16.4 uM for the binding of 14-3-3ζ or 14-3-3γ to PRAS40, respectively; effectively blocks the ability of all seven 14-3-3 isoforms to stimulate exoenzyme S (ExoS) ADP-ribosyltransferase (IC50=6-19 uM in a functional assay); also blocked the binding of 14-3-3 with Raf-1 and proline-rich AKT substrate, PRAS40.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    FOBISIN101
  • Pathway
    Others
  • Target
    14-3-3 Protein
  • Recptor
    14-3-3 Protein
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1370281-06-3
  • Formula Weight
    461.209
  • Molecular Formula
    C15H11N3Na3O8P
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    ——
  • Chemical Name
    4-[(2Z)-2-[4-formyl-6-methyl-5-oxo-3-(phosphonatooxymethyl)pyridin-2-ylidene]hydrazinyl]benzoate trisodium salt

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Zhao J, et al. Proc Natl Acad Sci U S A. 2011 Sep 27;108(39):16212-6. 2. Du Y, et al. J Biomol Screen. 2006 Apr;11(3):269-76. 3. Fu H, et al. Proc Natl Acad Sci U S A. 1993 Mar 15;90(6):2320-4.
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